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anticoagulants eg, warfarin , aspirin, clopidogrel, corticosteroids eg, prednisone , heparin and other blood thinners eg, dalteparin , or selective serotonin reuptake inhibitors ssris eg, fluoxetine because the risk of stomach bleeding may be increased acetaminophen because the risk of liver problems may be increased probenecid because it may increase the risk of diclofenac s side effects cyclosporine, lithium, metformin, methotrexate, oral nsaids eg, ibuprofen , or quinolones eg, ciprofloxacin because the risk of their side effects may be increased by diclofenac angiotensin-converting enzyme ace inhibitors eg, enalapril or diuretics eg, furosemide, hydrochlorothiazide because their effectiveness may be decreased by diclofenac.

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anticoagulants eg, warfarin , aspirin, clopidogrel, corticosteroids eg, prednisone , direct factor xa inhibitors eg, rivaroxaban , heparin, prasugrel, or selective serotonin reuptake inhibitors ssris eg, fluoxetine because the risk of bleeding, including stomach bleeding, may be increased azole antifungals eg, itraconazole, voriconazole , bisphosphonates eg, risedronate , or probenecid because they may increase the risk of diclofenac s side effects rifamycins eg, rifampin because they may decrease diclofenac s effectiveness cyclosporine, lithium, methotrexate, other nsaids eg, ibuprofen , quinolones eg, ciprofloxacin , or tenofovir because the risk of their side effects may be increased by diclofenac angiotensin-converting enzyme ace inhibitors eg, enalapril or diuretics eg, furosemide, hydrochlorothiazide because their effectiveness may be decreased by diclofenac medicines that may harm the liver eg, acetaminophen, ketoconazole, isoniazid, certain medicines for hiv infection, certain antibiotics or seizure medicines because the risk of liver side effects may be increased.

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