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St john s wort co-administration of digoxin with st john s wort should be avoided because plasma levels are significantly reduced.

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, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin that are eliminated by renal tubular secretion theoretically have the potential for interaction with glycomet by competing for common renal tubular transport systems.

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any arrhythmias or alteration in cardiac conduction that develops in a child taking digoxin should initially be assumed to be a consequence of digoxin intoxication.

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although amiodarone may increase serum digoxin levels, in our analysis, digoxin s deleterious effect on mortality persisted after adjustment for amiodarone use.
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The co-administration of digoxin and beta-blockers for example propranolol inderal, inderal la or calcium channel blockers or ccbs for example, verapamil , which also reduce heart rate, can cause serious heart rate slowing.

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