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the absolute oral bioavailability of pristiq after oral administration is about 80 .

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if concomitant use of pristiq with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases 5.

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the efficacy of pristiq has been established in four 8-week, placebo-controlled studies of outpatients who met dsm-iv criteria for major depressive disorder.

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