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While strong cyp3a4 inducers affect serum concentrations of both vandetanib and its active metabolite, n-desmethyl-vandetanib, indinavir is not expected to affect vandetanib exposure based on a crossover study n 14 in which no clinically significant interaction was noted between vandetanib and the strong cyp3a4 inhibitor itraconazole.

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taking indinavir at the same time each day will help you remember to take it.

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the recommended dosage of indinavir is 800mg orally every 8 hours.

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unfortunately, indinavir wears off quickly after dosing, so requires very precise dosing every eight hours to thwart hiv from forming drug-resistant mutations, including resistances to other protease inhibitors.


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