While strong cyp3a4 inducers affect serum concentrations of both vandetanib and its active metabolite, n-desmethyl-vandetanib, indinavir is not expected to affect vandetanib exposure based on a crossover study n 14 in which no clinically significant interaction was noted between vandetanib and the strong cyp3a4 inhibitor itraconazole.
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unfortunately, indinavir wears off quickly after dosing, so requires very precise dosing every eight hours to thwart hiv from forming drug-resistant mutations, including resistances to other protease inhibitors.
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